Lipotropin (AOD-9604)

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Lipotropin is a fragment of the Human Growth Hormone (GH FRAG 176-191) that restores the ability for the body to burn fat, therefore reducing body weight and without the growth stimulating activities associated with the Human Growth Hormone. In the lab, lipotropin has gone under the name of AOD-9604, adoption of the new trademark name of Lipotropin has been a little slow on the uptake. 

Lipotropin Peptide

A study of Ng et al. (2000) found that on animal subjects, a dose of 500mcg increased the lipolytic activity of adipose tissues without having a negative influence in the blood glucose level. Further, though it is a fragment of the growth hormone peptide it does not cause hyperglycemia because it does not compete with GH receptors (Wu et. al. 1993). As a result of these effects, researches have suggested that it might be used for the elimination of excess abdominal fat, a significant aspect of HIV associated lipodystrophy.

AOD-9604 uses the HGH fragment 176-191 at the C-terminal region. Studies have shown that it works by mimicking the natural HGH regulation of fat metabolism but without the advise insulin sensitivity effects or cell proliferation (muscle growth) that is seen with the unmodified Human Growth Hormone.  Like unmodified Growth Hormone, the Human Growth Hormone fragment 176-191 stimulates lipolysis (breaking down of fat) and inhibits lipogenesis (the formation of fatty acids and other lipids in the body).

Lipotropin is estimated to be 12.5 times stronger than HGH for the breaking down of fat, it also has the ability to increase muscle growth - but not as agressively as unmodified Human Growth Hormone.

In human studies, taking AOD-9604 as a subcutaneous injection several times a day can have the increased breaking down of fat effects without side effects associated with many obesity drugs.

The dosing in human studies ranged between 5-10mcg per KG, split into 2 - 3 dosages per day.

The dosing protocol for Human use is likely to be similar to the following:


250mcg in the morning before eating
250mcg pre lunch
250mcg in the evening before bed

Approximately 5-7 days a week - subcutaneous injections


350mcg in the morning before eating
350mcg 30 minutes prior to training or prior to eating
350mcg in the evening before bed

Approximately 5-7 days a week - subcutaneous injections

Lipotropin is not yet approved for use in Humans. 


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